Cold Agglutinins. Vi. Agglutinins for an Indifferent Streptococcus in Primary Atypical Pneumonia and in Other Conditions and Their Relation to Cold Isohemagglutinins.

Observations on Certain Sero- Logical and Physical Features of Cold Agglutinins in Cases of Primary Atypical Pneumonia and of Hemolytic Anemia

Some of the properties of cold agglutinins in certain human sera have been listed in a recent review (1). The knowledge concerning these properties is based on studies of the phenomenon by various methods in serum or plasma from isolated cases of a large variety of conditions. With respect to the cold agglutinins in cases of primary atypical pneumonia, limited studies of certain aspects were re...

Cold Agglutinins. Ii. Cold Isohemagglutinins in Primary Atypical Pneumonia of Unknown Etiology with a Note on the Occurrence of Hemolytic Anemia in These Cases.

In the preceding paper ( 1), there was presented a summary of the maximum titers of cold agglutinins found in 1069 cases of a variety of conditions, including the various infections of the respiratory tract that are commonly encountered in this vicinity. Significant titers (in dilutions greater than 20) were obtained only in cases of primary atypical pneumonia of unknown etiology,' and in a few...

Problems of Cold Agglutinins in Cardiac Surgery: How to Manage Cardiopulmonary Bypass and Myocardial Protection

Cold agglutinins are of unique relevance in cardiac surgerybecause of the use of hypothermic cardiopulmonary bypass (CPB). Cold autoimmune diseases are defined by the presence of abnormal circulating proteins (usually IgM or IgA antibodies) that agglutinate in response to a decrease in body temperature. These disorders include cryoglobulinemia and cold hemagglutinin disease.Immunoglobulin M aut...

Cold Agglutinins. v. Deterioration of Cold Isohemagglutinins on Storage.

Acute Haemolytic Anaemia.

Acute haemolytic anaemia associated with high titre cold agglutinins is an uncommon complication of primary atypical pneumonia. The first description of a case appears in a paper of Clough and Richter4 recording their observations on the haemagglutinins in a patient with bronchopneumonia. In the British literature Besterman and Brigden2 first reported a case and in surveying the literature foun...